Detalhe da pesquisa
1.
From structure to clinic: Design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer's disease.
Cell
; 184(24): 5886-5901.e22, 2021 11 24.
Artigo
em Inglês
| MEDLINE | ID: mdl-34822784
2.
Safety, pharmacokinetics and pharmacodynamics of HTL0009936, a selective muscarinic M1 -acetylcholine receptor agonist: A randomized cross-over trial.
Br J Clin Pharmacol
; 87(11): 4439-4449, 2021 11.
Artigo
em Inglês
| MEDLINE | ID: mdl-33891333
3.
First-in-man study to investigate safety, pharmacokinetics and exploratory pharmacodynamics of HTL0018318, a novel M1 -receptor partial agonist for the treatment of dementias.
Br J Clin Pharmacol
; 87(7): 2945-2955, 2021 07.
Artigo
em Inglês
| MEDLINE | ID: mdl-33351971
4.
A phase 1b/2a multicenter study of the safety and preliminary pharmacodynamic effects of selective muscarinic M1 receptor agonist HTL0018318 in patients with mild-to-moderate Alzheimer's disease.
Alzheimers Dement (N Y)
; 8(1): e12273, 2022.
Artigo
em Inglês
| MEDLINE | ID: mdl-35229025
5.
Safety and Pharmacokinetics of HTL0018318, a Novel M1 Receptor Agonist, Given in Combination with Donepezil at Steady State: A Randomized Trial in Healthy Elderly Subjects.
Drugs R D
; 21(3): 295-304, 2021 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-34164794
6.
Safety, pharmacokinetics and exploratory pro-cognitive effects of HTL0018318, a selective M1 receptor agonist, in healthy younger adult and elderly subjects: a multiple ascending dose study.
Alzheimers Res Ther
; 13(1): 87, 2021 04 21.
Artigo
em Inglês
| MEDLINE | ID: mdl-33883008
7.
Cholinergic muscarinic M1 and M4 receptors as therapeutic targets for cognitive, behavioural, and psychological symptoms in psychiatric and neurological disorders.
Drug Discov Today
; 24(12): 2307-2314, 2019 12.
Artigo
em Inglês
| MEDLINE | ID: mdl-31499186
8.
Treatment of elderly primary insomnia patients with EVT 201 improves sleep initiation, sleep maintenance, and daytime sleepiness.
Sleep Med
; 11(1): 23-30, 2010 Jan.
Artigo
em Inglês
| MEDLINE | ID: mdl-19945340
9.
The partial positive allosteric GABA(A) receptor modulator EVT 201 is efficacious and safe in the treatment of adult primary insomnia patients.
Sleep Med
; 10(8): 859-64, 2009 Sep.
Artigo
em Inglês
| MEDLINE | ID: mdl-19345644